• Are cultured human myotubes far from home? 

      Aas, Vigdis; Bakke, Siril Skaret; Feng, Yuan Zeng; Kase, Eili Tranheim; Jensen, Jørgen; Bajpeyi, Sudip; Thoresen, G. Hege; Rustan, Arild (Cell and tissue research;354(3), Journal article; Peer reviewed, 2013-12)
      Satellite cells can be isolated from skeletal muscle biopsies, activated to proliferating myoblasts and differentiated into multinuclear myotubes in culture. These cell cultures represent a model system for intact human ...
    • Electrical Pulse Stimulation of Cultured Human Skeletal Muscle Cells as an In Vitro Model of Exercise 

      Nikolić, Nataša; Bakke, Siril Skaret; Kase, Eili Tranheim; Rudberg, Ida; Halle, Ingeborg Flo; Rustan, Arild C.; Thoresen, G. Hege; Aas, Vigdis (PLoS ONE;7 (3), Peer reviewed; Journal article, 2012-03-22)
      Background and Aims Physical exercise leads to substantial adaptive responses in skeletal muscles and plays a central role in a healthy life style. Since exercise induces major systemic responses, underlying cellular ...
    • Myotubes from Severely Obese Type 2 Diabetic Subjects Accumulate Less Lipids and Show Higher Lipolytic Rate than Myotubes from Severely Obese Non-Diabetic Subjects 

      Bakke, Siril Skaret; Feng, Yuan Zeng; Nikolic, Natasa; Kase, Eili Tranheim; Moro, Cedric; Stensrud, Camilla; Damlien, Lisbeth; Ludahl, Marianne Odnakk; Sandbu, Rune; Solheim, Brita Marie; Rustan, Arild; Hjelmesæth, Jøran; Thoresen, G. Hege; Aas, Vigdis (Journal article; Peer reviewed, 2015-03-19)
      About 80% of patients with type 2 diabetes are classified as overweight. However, only about 1/3 of severely obese subjects have type 2 diabetes. This indicates that several se- verely obese individuals may possess certain ...
    • Remodelling of oxidative energy metabolism by galactose improves glucose handling and metabolic switching in human skeletal muscle cells 

      Kase, Eili Tranheim; Nikolić, Nataša; Bakke, Siril Skaret; Bogen, Kaja Kamilla; Aas, Vigdis; Thoresen, G. Hege; Rustan, Arild Christian (Journal article; Peer reviewed, 2013-04-01)
      Cultured human myotubes have a low mitochondrial oxidative potential. This study aims to remodel energy metabolism in myotubes by replacing glucose with galactose during growth and differentiation to ultimately examine the ...